Cart
sales@molnova.com
Home - Products - Cytoskeleton/Cell Adhesion Molecules - Akt - I-CBP112 hydrochloride

I-CBP112 hydrochloride

CAS No. 2147701-33-3

I-CBP112 hydrochloride ( —— )

Catalog No. M17434 CAS No. 2147701-33-3

I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 133 Get Quote
5MG 224 Get Quote
10MG 424 Get Quote
25MG 696 Get Quote
50MG 972 Get Quote
100MG 1314 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    I-CBP112 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains.
  • Description
    I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly reduced the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. Interestingly, I-CBP112 increased the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin.
  • Synonyms
    ——
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    CBP/p300, Leukemia cell; CBP/p300, Prostate cancer cell
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2147701-33-3
  • Formula Weight
    505
  • Molecular Formula
    C27H36N2O5HCl
  • Purity
    98%
  • Solubility
    ——
  • SMILES
    CCC(=O)N1CCOC2=C(C1)C=C(C=C2OC[C@H]3CCCN(C3)C)C4=CC(=C(C=C4)OC)OC.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zucconi BE, et al. Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain LigandI-CBP112. Biochemistry. 2016 Jul 12;55(27):3727-34.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Cariprazine

    Cariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).

  • Sennidin A

    Sennidin A has two hydroxyanthraquinone-like moieties exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.

  • Monoammonium glycyrr...

    Monoammonium glycyrrhizinate is extracted from Such sweet licorice root.

Sign In Join Free